What to know about taking Wegovy with Adderall

Wegovy is not known to interact with Adderall. It’s likely safe to take these medications together, but check with a doctor first because these drugs can have some similar side effects.
Wegovy (semaglutide) is a chronic weight management medication approved by the Food and Drug Administration (FDA) for use in some people with obesity or overweight. It’s also approved to reduce serious cardiovascular risks.
chronic weight management
obesity
cardiovascular
Adderall (amphetamine/dextroamphetamine) is approved to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy.
attention deficit hyperactivity disorder (ADHD)
narcolepsy
In medical terms, an interaction is when one substance causes another to have a different effect than expected. An interaction can occur with another drug or with foods or supplements. Drug interactions may increase the risk of side effects or change the effectiveness of either or both drugs.
Keep reading to learn about interactions between Wegovy, Adderall, and related medications. For other information, including details about their uses, see these articles about Wegovy and Adderall.
Wegovy
Adderall
Wegovy, Adderall, and other ADHD medications
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Wegovy is a glucagon-like peptide-1 receptor agonist (commonly known as a GLP-1 medication). Adderall is a central nervous system (CNS) stimulant.
glucagon-like peptide-1 receptor agonist
central nervous system (CNS) stimulant
There are no reports of Wegovy interacting with Adderall or other ADHD medications. This includes other CNS stimulants, such as lisdexamfetamine (Vyvanse), and nonstimulants, such as atomoxetine (Strattera).
reports
ADHD medications
Vyvanse
Strattera
However, GLP-1s may affect how your body absorbs oral drugs (drugs taken by mouth). (Adderall is an oral drug.) Additionally, Wegovy and ADHD medications can cause some of the same side effects (discussed later in this article).
may affect
GLP-1s slow down the movement of food through your stomach and into your small intestine. Changes in the way your body absorbs a drug may affect the level of the drug in your system. In turn, this may change how effective the drug is in treating your condition.
Semaglutide (the GLP-1 in Wegovy) did not affect the absorption of the medications studied in clinical trials. (Adderall was not among those medications.) Still, it’s important to monitor for changes if you’re taking oral drugs with Wegovy.
clinical trials
If you take Adderall (or another ADHD medication) and use Wegovy, talk with your doctor if you notice any differences in how either medication is working to treat your condition.
Wegovy, Adderall, and other ADHD medications, such as methylphenidate (Ritalin, Concerta, others), can cause some similar side effects. These include reduced appetite and digestive symptoms such as nausea, vomiting, and diarrhea.
such as
Ritalin
Concerta
reduced appetite
diarrhea
These symptoms may reduce your nutrient intake, which may lead to weight loss. Using Wegovy with an ADHD medication may amplify this effect. While Wegovy is intended to help with weight loss, losing too much weight or losing it too quickly can have negative effects, such as gallstones.
nutrient
weight loss
negative effects
gallstones
For this reason, be sure to get enough nutrient-dense foods in your diet. If you’d like more help in this area, talk with your doctor or ask whether they can recommend a dietitian.
nutrient-dense foods
dietitian
Learn more about the side effects of Wegovy and Adderall.
Wegovy
Adderall
Medications you should not take with Wegovy
Doctors typically will not prescribe Wegovy in combination with:
will not
other GLP-1s, such as liraglutide (Saxenda and Victoza)
Saxenda
Victoza
tirzepatide (Mounjaro and Zepbound)
Mounjaro
Zepbound
The list below includes other drugs that interact with Wegovy. Doctors use caution when prescribing any of these drugs with Wegovy:
diabetes drugs that lower blood sugar, including insulin, sulfonylureas, and meglitinides
diabetes drugs
insulin
levothyroxine (Synthroid, Unithroid)
Synthroid
beta-blockers
beta-blockers
selective serotonin reuptake inhibitors (SSRIs)
selective serotonin reuptake inhibitors (SSRIs)
androgens
androgens
quinolones (a class of antibiotics)
antibiotics
salicylates
salicylates
certain diuretics, including furosemide (Lasix) and thiazides
diuretics
furosemide
There are other interactions with Wegovy, including certain minerals, supplements, and foods. Always check with a doctor before using Wegovy with other substances. They can check for any potential interactions.
other interactions
To learn about Adderall’s interactions, see this article.
this article
Things to consider
Off-brand or compounded semaglutide products may contain different active ingredients than FDA-approved semaglutide medications. These products could contain ingredients that may interact with other drugs or other substances you may be taking.
may contain
Also, compounded products may not be safe or effective. Always purchase semaglutide products with a prescription from a licensed healthcare professional.
Summary
Wegovy and Adderall are not known to interact. However, Wegovy may have a small effect on your body’s absorption of oral medications such as Adderall.
Also, Wegovy and ADHD medications can cause some of the same side effects, including reduced appetite. If you use these medications together, you may need to take steps to ensure that you get enough nutrients in your diet.
Your doctor can determine whether this combination of medications is right for you. To reduce the risk of drug interactions, it’s important to discuss all medications, supplements, herbs, and vitamins you’re taking with a doctor or pharmacist.